Sultamicillin is generally well tolerated. The majority of side effects observed were of mild or moderate severity and were normally tolerated with continued treatment.
Infections and Infestations: Pseudomembranous colitis, Candida infection.
Blood and Lymphatic System Disorders: Thrombocytopenia.
Immune System Disorders: Anaphylactic shock, Anaphylactic reaction, Hypersensitivity.
Nervous System Disorders: Dizziness, Somnolence, Sedation, Headache.
Respiratory, Thoracic and Mediastinal Disorders: Dyspnea.
Gastrointestinal Disorders: Enterocolitis, Melena, Diarrhea, Vomiting, Abdominal pain, Dyspepsia, Nausea, Stomatitis, Dysgeusia, Tongue discoloration.
Hepatobiliary Disorders: Jaundice, Hepatic function abnormal (see Precautions).
Skin and Subcutaneous Tissue Disorders: Toxic epidermal necrolysis, Stevens-Johnson syndrome, Erythema multiforme (see Precautions), Angioedema, Urticaria, Dermatitis, Rash, Pruritus.
Musculoskeletal and Connective Tissue Disorders: Arthralgia.
General Disorders and Administration Site Conditions: Fatigue, Malaise.
Investigations: Alanine aminotransferase increased, Aspartate aminotransferase increased (see Precautions).
Adverse reactions associated with the use of ampicillin alone and/or sulbactam/ampicillin IM/IV may be observed with sultamicillin. These include: Blood and Lymphatic System Disorders: Agranulocytosis, Hemolytic anemia, Thrombocytopenic purpura, Leukopenia, Neutropenia, Eosinophilia, Anemia.
Immune System Disorders: Anaphylactoid shock, Anaphylactoid reaction.
Nervous System Disorders: Convulsion.
Gastrointestinal Disorders: Glossitis.
Hepatobiliary Disorders: Hepatitis cholestatic, Cholestasis, Hyperbilirubinemia, (see Precautions).
Skin and Subcutaneous Tissue Disorders: Dermatitis exfoliative, Acute generalized exanthematous pustulosis (see Precautions).
Renal and Urinary Disorders: Tubulointerstitial nephritis.
Investigations: Platelet aggregation abnormal.