Increased risk of myopathy w/ cyclosporine, gemfibrozil/fibric acid derivatives, erythromycin, azole antifungals or niacin. Increased plasma conc w/ CYP450 3A4 inhibitors (eg, macrolide antibiotics, grapefruit juice & PIs), substrates & other drugs metabolized by this isoenzyme. Increased risk of myopathy & bioavailability w/ P-glycoprotein inhibitors. May increase conc of digoxin, OC-containing norethisterone & ethinyl estradiol. Reduced plasma conc w/ colestipol, oral antacid susp containing Mg & Al hydroxides. Minimal decrease in prothrombin time w/ warfarin.