Tablet: Side effects of dicycloverine hydrochloride are dryness of the mouth, with difficulty in swallowing and talking, thirst, dilatation of the pupils (mydriasis) with loss of accommodation (cycloplegia) and photophobia, flushing and dryness of the skin, constipation and headache.
Toxic doses cause tachycardia, rapid respiration, hyperpyrexia and CNS stimulation marked by restlessness, confusion, excitement, paranoid and psychotic reactions, hallucinations and delirium and occasionally seizures and convulsion.
Treatment of Adverse Effects:
If overdoses have been taken by mouth, the stomach should be emptied by aspiration and lavage or by induction of emesis. The giving of activated charcoal to reduce absorption prior to lavage has been suggested.
Syrup: Adverse effects with dicycloverine are usually related to its pharmacological actions of inhibiting muscarinic receptors, including dry mouth, dizziness, blurred vision, nausea, light-headedness, somnolence, asthenia, and nervousness. These effects are dose-related and are usually reversible when treatment is discontinued.
The most serious adverse reactions reported include cardiovascular and nervous system effects (see Precautions).
Other adverse effects include: Immune System:
Drug hypersensitivity including facial edema, angioedema, anaphylactic shock.
Agitation, altered mood, amnesia (or transient global amnesia), confused state, delirium, delusion, disorientation, hallucination (including visual hallucination), mania, pseudodementia.
Dyskinesia, headache, insomnia, numbness, speech disturbance, syncope, tingling.
Cycloplegia, diplopia, increased ocular tension, mydriasis.
Hypertension palpitations, tachyarrhythmias.
Respiratory, Thoracic and Mediastinal:
Apnea, dyspnea, nasal congestion, sneezing, throat congestion.
Abdominal distention/pain, anorexia, constipation, dyspepsia, vomiting.
Skin and Subcutaneous Tissue:
Allergic dermatitis, decreased sweating, erythema, itching, rash, urticaria.
Impotence, suppressed lactation, urinary hesitancy, urinary retention.
General Disorders and Administration Site Conditions: