RiteMED Diphenhydramine HCl

RiteMED Diphenhydramine HCl

diphenhydramine

Manufacturer:

RiteMED

Distributor:

United Lab
Concise Prescribing Info
Contents
Diphenhydramine HCl
Indications/Uses
Relief of symptoms associated w/ seasonal, perennial vasomotor rhinitis. Allergic conjunctivitis due to foods. Mild, uncomplicated allergic skin manifestations of urticaria & angioedema; amelioration of allergic reactions to blood or plasma. Dermatographism. Anaphylactic reactions adjunctive to epinephrine & other standard measured after acute manifestations have been controlled. Parkinsonism in the elderly; mild cases of parkinsonism in other age groups; in other cases of parkinsonism in combination w/ centrally-acting anticholinergic agents. Short-term management of insomnia. Relief of cough by minor throat & bronchial irritation. Prevention & treatment of nausea, vomiting &/or dizziness associated w/ motion sickness.
Dosage/Direction for Use
Antihistamine & antiparkinsonism 1 cap every 6 hr. Nighttime sleeping aid 1 cap 20 min before going to bed. Antitussive 1 cap every 8 hr. Motion sickness 1 cap 30 min before exposure to motion. Subsequent doses may be given every 6 hr at bedtime. Max: 300 mg in 24 hr. Renal impairment Dosage intervals: 6-12 hr.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Asthma attack, narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer & pyloroduodenal obstructions predisposing to increased risk of GI obstruction, bladder-neck obstruction, porphyria. Patients receiving antidepressant therapy. Lactation. Premature infants & neonates.
Special Precautions
Liver disease, glaucoma, urinary retention, myasthenia gravis, seizure disorders, hyperthyroidism, CV disease or HTN. Do not use w/ other antihistamines, sedatives or tranquilizers; avoid alcohol, other diphenhydramine-containing products including topical formulations. Avoid use >7-10 nights. Insomnia persisting continuously for >2 wk. Avoid driving or performing other tasks requiring complete mental alertness w/in 8 hr. Pregnancy. Elderly. Childn.
Adverse Reactions
Fatigue, hypersensitivity reactions (eg, bronchospasm, anaphylaxis, angioedema); tachycardia, palpitations, hypotension; dry mouth, GI disturbance including nausea & vomiting, diarrhea; blood disorders; liver dysfunction; muscle twitching, muscular weakness, myalgia; sedation, drowsiness, attention disturbance, unsteadiness, dizziness, convulsions, headache, paresthesia, dyskinesia, confusion, paradoxical excitation (eg, increased energy, restlessness, nervousness), incoordination, euphoria, extrapyramidal effects, depression, sleep disturbances, tremors; urinary difficulty/retention, dysuria; thickening of bronchial secretions, chest tightness, dyspnea; rash, urticaria, photosensitivity reactions, sweating, hair loss; blurred vision, tinnitus.
Drug Interactions
Additive effects w/ alcohol & other CNS depressants including barbiturates, tranquilizers, hypnotics, sedatives, anti-anxiety agents & narcotic analgesics. Prolonged anticholinergic & CNS depresssant effects w/ MAOIs eg, phenelzine, tranylcypromine, isocarboxazid, furazolidone, procarbazine. Potentiates anticholinergic side effects w/ other anticholinergic drugs eg, atropine. May increase plasma conc & CV effects of β-blockers (metoprolol, carvedilol, labetalol, propranolol, timolol). May reduce absorption of para-aminosalicylic acid.
MIMS Class
Antihistamines & Antiallergics
ATC Classification
R06AA02 - diphenhydramine ; Belongs to the class of aminoalkyl ethers used as systemic antihistamines.
Presentation/Packing
Form
RiteMED Diphenhydramine HCl cap 50 mg
Packing/Price
100's (P8.5/cap, P850/box)
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