RiteMED Glimepiride

RiteMED Glimepiride





United Lab
Concise Prescribing Info
Dosage/Direction for Use
Starting dose: 1 mg once daily. Max starting dose: 2 mg once daily. Maintenance: 1-4 mg once daily. Max: 8 mg once daily. After reaching a dose of 2 mg, any increase in dosage should be in increments of not >1 mg at 1-2 wk intervals based on the patient's glucose response.
Should be taken with food: Take immediately before or during breakfast/1st main meal of the day. Do not skip meals.
Hypersensitivity to glimepiride or other sulfonylureas. Type 1 diabetes. Severe renal or hepatic insufficiency. Diabetic ketoacidosis w/ or w/o coma. Pregnancy & lactation.
Special Precautions
Allergy to other sulfonamide derivatives. Increased risk of CV mortality, hypoglycemia, loss of blood glucose control. Hemolytic anemia in patients w/ G6PD deficiency. Renal, hepatic, adrenal or pituitary insufficiency. May impair ability to drive or operate machinery. Childn. Elderly >65 yr, debilitated or malnourished patients.
Adverse Reactions
Hypo- & hyperglycemia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion, aggravation of DM, hyponatremia, increased appetite, anorexia. GI disturbances; bradycardia, palpitations, vasodilation; hematologic, immune system, CNS, hepatobiliary & skin & subcutaneous tissue disorders. Asthenia, pain in extremity, allergic vasculitis, sweating, visual disturbance/abnormal vision, increase urinary frequency, nocturia.
Drug Interactions
Increased mean AUC & decreased mean Cmax w/ aspirin. Increased Cmax, AUC & t½ w/ propranolol. Severe hypoglycemia w/ oral miconazole. Reduced mean area under prothrombin time (PT) curve & max PT values w/ coumarin anticoagulants. CYP450 2C9 inhibitors, inducers & substrates. Reduced or absence of signs of adrenergic counter-regulation to hypoglycemia w/ sympatholytic agents (β-blockers, clonidine, guanethidine & reserpine). Potentiated or reduced activity w/ acute or chronic alcohol intake. Hypoglycemic action potentiated w/ NSAIDs (eg, ibuprofen, phenylbutazone, oxyphenbutazone & azapropazone), clarithromycin, highly protein-bound drugs, coumarins, probenecid, β-blockers, salicylates, aminosalicylic acid, anabolic steroids & male sex hormones, chloramphenicol, long-acting sulfonamides, tetracyclines, quinolones, coumarin anticoagulants, fenfluramine, fibrates, ACE inhibitors, fluoxetine, MAOIs, disopyramide, allopurinol, probenecid, sulfinpyrazone, sympatholytics, cyclophosphamide, trosphosphamide, ifosfamide, miconazole, fluconazole, pentoxifylline (high dose parenteral), tritoqualine, insulin & other oral antidiabetic drugs. Hyperglycemia & loss of glycemic control w/ thiazides & other diuretics, corticosteroids, phenothiazines, chlorpromazine, thyroid products, estrogen, progestogens, nicotinic acid (high doses) & derivatives, laxatives (long-term use), OCs, phenytoin, diazoxide, glucagon, barbiturates, rifampicin, acetazolamide, adrenaline, sympathomimetics & INH.
MIMS Class
ATC Classification
A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
RiteMED Glimepiride tab 3 mg
100's (P10.85/tab, P1,085/box)
RiteMED Glimepiride tab 2 mg
100's (P9/tab, P900/box)
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