If patient is allergic to loperamide or any ingredient in the product.
If patient is a child under 12 years old.
If patient is pregnant or breastfeeding.
If patient is constipated and also in whom constipation should be avoided (e.g., Diarrhea resulting from infections).
If the abdomen is swelling or has abdominal pain.
If patient has acute dysentery which is characterized by blood in stools and high fever.
If patient has acute pseudomembranous colitis (diarrhea associated with antibiotics), active ulcerative colitis, meningitis or a history of liver disease.