Limited data is currently available on acute overdosage with sildenafil. Single oral doses of up to 800 mg in healthy volunteers have been shown to have similar adverse events to those seen at lower doses. However, incidence rates and severities were increased in these patients.
Sildenafil overdosage is generally expected to result in extensions of the common adverse reactions to the drug. Increased efficacy was not found with 200 mg dose. However, the incidence of adverse reactions such as headache, flushing, dizziness, dyspepsia, nasal congestion, and altered vision was increased.
Manage sildenafil overdosage with standard supportive measures and therapy.
Since sildenafil is highly bound to plasma proteins and renal clearance is not the major elimination pathway, renal dialysis is not expected to enhance sildenafil clearance in case of overdosage.