Each film-coated tablet contains: Cefuroxime (as Axetil) 500 mg.
Pharmacology: Pharmacokinetics: Cefuroxime (as Axetil) is absorbed from the gastro-intestinal tract and is rapidly hydrolyzed in the intestinal mucosa and blood to cefuroxime. The absorption of Cefuroxime (as Axetil) is enhanced in the presence of food. Peak plasma concentrations are reported about 2 to 3 hours after oral dose.
Used in the treatment of susceptible infections. These includes bone and joint infections, bronchitis, gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, skin and soft tissue infections, surgical infection and urinary tract infections.
Usual oral doses are 125 mg twice daily for uncomplicated urinary tract infections and 250 to 500 mg twice daily for respiratory tract infections. A suggested dose for children more than 3 months of age is 125 mg twice daily or 10 mg per kg body-weight twice daily to a maximum of 250 mg daily. Children over 2 years of age with otitis media may be given 250 mg twice daily or 15 mg per kg twice daily to a maximum of 500 mg daily.
Cefuroxime (as Axetil) should not be given to patients who are hypersensitive to it or other cephalosporins. Care is also necessary in patients with known histories of allergy.
Gastro-intestinal disturbances, including diarrhea, and vomiting, have occurred in some patients receiving Cefuroxime (as Axetil). There have been rare reports of erythema multiforme, including the Stevens-Johnson syndrome, and toxic epidermal necrolysis.
Store at temperatures not exceeding 30°C.
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.