Roximed Mechanism of Action





Full Prescribing Info
Pharmacology: Pharmacokinetics: Following oral administration, Roxithromycin is well absorbed, with a bioavailability of about 50%. Peak plasma concentrations of about 6 to 8 μg/mL occurring around 2 hours after a single dose of 150 mg. Absorption is reduced when taken after, but not before, a meal. It is widely distributed in tissues and body fluids. It is reported to be about 96% bound to plasma protein (mainly a,-acid glycoprotein) at trough concentrations, but binding is saturable, and only about 86% is bound at usual peak concentrations. Small amounts of roxithromycin are metabolized in the liver, and the majority of a dose is excreted in the feces as unchanged drug; about 7 to 12% is excreted in the urine and up to 15% via the lungs. The elimination half-life is reported to range between about 8 to 13 hours, but may be more prolonged in children.
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