The most common are hypersensitivity reactions, including skin rashes, urticaria, eosinophilia, fever, reactions resembling serum sickness, and anaphylaxis. There may be a positive response to the Coombs' test although haemolytic anaemia rarely occurs. Neutropenia and thrombocytopenia have occasionally been reported. Agranulocytosis has been associated rarely with some cephalosporins. Bleeding complications related to hypoprothrombinaemia and/or platelet dysfunctions have occurred especially with cephalosporins and cephamycins having a N-methylthiotetrazole side-chain, including cefamandole, and latamoxef. The presence of a methylthiadiazolethiol side-chain, as in cefazolin, or a N-methylthiotriazine ring, as ceftriaxone, might also be associated with such bleeding disorders.
ADR Reporting Statement: Seek medical attention immediately at the first sign of any adverse drug reaction.