Salicylic acid

Generic Medicine Info
Indications and Dosage
Hyperkeratotic and scaling skin conditions
Adult: As 1.8-3% preparation: Apply to affected area of the skin and/or scalp 1-4 times daily.

Adult: As 0.5-2% preparation: Apply thinly to affected area 1-3 times daily, reduce to once daily or every other day if dryness or peeling occur.

Callus, Warts
Adult: As 12-40% plaster: Fit over the wart/callus for 48 hr, repeat process 48 hrly as needed until wart/callus is removed (up to 12 wk for warts or up to 14 days for calluses). As 5-17% preparation in collodion-like vehicle: Apply a small amount to sufficiently cover wart/callus and allow to dry. Repeat 1-2 times daily until wart/callus is removed (up to 12 wk for warts or up to 14 days for calluses). As 15% preparation in karaya gum-glycol plaster vehicle: Smoothen warts w/ emery board and place a drop of warm water prior to application. Apply the plaster in the evening and leave in place for at least 8 hr to be removed in the morning. Repeat process 24 hrly, if necessary up to 12 wk.
Wart/callus removal preparations: Diabetes or impaired blood circulation. Use on moles, birthmarks and unusual warts w/ growing hair or warts on the face.
Special Precautions
Patient w/ impaired peripheral circulation or diabetes, significant peripheral neuropathy.
Adverse Reactions
Dermatitis, skin peeling, discomfort, irritation, dryness, ulceration or erosion; systemic effects including salicylate toxicity (e.g. nausea, vomiting, dizziness, lethargy, hyperpnoea, diarrhoea, and psychosis), and toxic inner ear damage.
Potentially Fatal: Rarely, serious hypersensitivity reactions (e.g. anaphylactic reaction).
Patient Counseling Information
Avoid use on broken skin, mouth, eyes, mucous membranes and anogenital region.
Monitor for signs of salicylate toxicity. Sensitivity testing for 1st time users.
Drug Interactions
Increased risk of skin dryness and irritation w/ other topical acne preparations.
Description: Salicylic acid has a potent keratolytic action and a slight antiseptic action when applied topically. It softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate. At high concentrations, salicylic acid has a caustic effect. It also possesses weak antifungal and antibacterial activity.
Onset: Treatment of warts: 1-2 wk.
Absorption: Readily absorbed through the skin.
Distribution: Plasma protein binding: 50-80%, to albumin.
Excretion: Via urine [salicyluric acid (52%), salicylate glucuronides (42%) and salicylic acid (6%)].
Chemical Structure

Chemical Structure Image
Salicylic acid

Source: National Center for Biotechnology Information. PubChem Database. Salicylic acid, CID=338, (accessed on Jan. 21, 2020)

Store between 15-30ºC.
Anon. Salicylic acid (Topical). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. Accessed 16/06/2016.

Anon. Salicylic acid. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 16/06/2016.

Buckingham R (ed). Salicylic acid. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 16/06/2016.

Compound W Gel (Medtech Products Inc.). DailyMed. Source: U.S. National Library of Medicine. Accessed 16/06/2016.

Joint Formulary Committee. Salicylic acid. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 16/06/2016.

Disclaimer: This information is independently developed by MIMS based on Salicylic acid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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