Salofalk

Salofalk Drug Interactions

mesalazine

Manufacturer:

Falk

Distributor:

Zuellig

Marketer:

A. Menarini
Full Prescribing Info
Drug Interactions
Tablet: Specific interaction studies have not been performed.
In patients who are concomitantly treated with azathioprine, 6-mercaptopurine or thioguanine, a possible increase in the myelosuppressive effects of azathioprine, 6-mercaptopurine or thioguanine should be taken into account.
There is weak evidence that mesalazine might decrease the anticoagulant effect of warfarin.
Enema/Suppository: The hypoglycemic action of the sulfonylureas can be intensified, as can gastrointestinal hemorrhage caused by coumarins. The toxicity of methotrexate can be increased. The uricosuric action of probenecid and sulfinpyrazone can be decreased, as can the diuretic action of furosemide and the action of spironolactone. The antituberculosis action of rifampicin can also be diminished. The gastric side effects of glucocorticoids can be increased.
One case of pancytopenia has been reported during treatment with mesalazine in combination with mercaptopurine.
Granules: Specific interaction studies have not been performed.
Lactulose or similar preparations which lower stool pH: Possible reduction of mesalazine release from granules due to decreased pH caused by bacterial metabolism of lactulose.
In patients who are concomitantly treated with azathioprine, 6-mercaptopurine or thioguanine, a possible increase in the myelosuppressive effects of azathioprine, 6-mercaptopurine or thioguanine should be taken into account.
There is weak evidence that mesalazine might decrease the anticoagulant effect of warfarin.
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