Body as a whole: Very common: Falls in the elderly. Common: Accidental injury, fever, back pain, pain in extremity, asthenia, fatigue. Uncommon: Chills, face edema. Rare: Chills and fever, neck pain, neck rigidity. Unknown: Hypothermia, neonatal drug withdrawal syndrome.
Cardiovascular: Common: Postural hypotension, chest pain, tachycardia, hypertension. Uncommon: Bradycardia, cerebrovascular accident, vasodilation, QTC prolongation, venous thromboembolism (including pulmonary embolism and deep vein thrombosis), syncope. Unknown: Ventricular tachycardia/fibrillation.
Endocrine and Metabolic: Very Common: Weight gain, elevated prolactin. Common: Increased appetite, peripheral edema, edema, glycosuria, elevated cholesterol levels, hyperglycemia, elevated triglyceride levels, elevated creatine kinase levels, increased uric acid levels. Uncommon: Bilirubinemia, hypoproteinemia, decreased libido, impotence, increased alkaline phosphatase acidosis, hypoglycemia, hypokalemia, hyponatremia, lower or upper extremity edema. Rare: Exacerbation of pre-existing diabetes, goiter, gout, hypernatremia, ketosis, water intoxication. Unknown: Diabetic coma, diabetic ketoacidosis.
Gastrointestinal: Common: Mild transient anticholinergic effects (e.g., constipation, dry mouth), dyspepsia, vomiting, increased salivation, thirst, nausea, abdominal pain, diarrhea, flatulence. Uncommon: Nausea and vomiting, tongue edema, abdominal distension, dysphagia, esophagitis, fecal impaction, fecal incontinence, gastritis, gastroenteritis, gingivitis, melena, mouth ulceration, oral moniliasis, periodontal abscess, rectal hemorrhage, stomatitis, tooth caries. Rare: Ileus, intestinal obstruction, aphthous stomatitis, enteritis, eructation, esophageal ulcer, glossitis, tongue discoloration. Unknown: Pancreatitis.
Hematologic: Common: Ecchymosis, eosinophilia. Uncommon: Leukopenia, neutropenia. Unknown: Thrombocytopenia Hepatic: Common: Increased liver enzymes (ALT, AST). Rare: Fatty deposit in the liver. Very Rare: Cholestatic or mixed liver injury. Unknown: Jaundice, hepatic failure, hepatitis (including hepatocellular).
Musculoskeletal: Common: Extremity pain (other than joint), joint pain, arthralgia, musculoskeletal stiffness, twitching. Uncommon: Arthritis, arthrosis, leg cramps, myasthenia. Rare: Osteoporosis, bone pain, bursitis, myopathy, rheumatoid arthritis, rhabdomyolysis.
Nervous system: Common: Dizziness, personality disorder, akathisia, somnolence, tremor, insomnia, abnormal gait, hypertonia, articulation impairment, speech disorder, amnesia, paresthesia, depression, apathy, confusion, euphoria, incoordination, extrapyramidal symptoms (dystonic, parkinsonism, dyskinetic, and residual events), sedation, headache, restlessness, agitation, hostility, anxiety, neurosis, hallucinations, abnormal dreams, delusions, emotional lability, manic reaction, schizophrenic reaction. Uncommon: Suicide attempt, ataxia, dysarthria, stupor, seizures, alcohol misuse, antisocial reaction, CNS stimulation, delirium, dementia, depersonalization, facial paralysis, hypesthesia, hypokinesia, obsessive-compulsive symptoms, phobias, somatization, stimulant misuse, stuttering, vertigo, withdrawal syndrome (diaphoresis, nausea or vomiting). Rare: Hangover effect, sudden death, coma, circumoral paresthesia, encephalopathy, neuralgia, neuropathy, nystagmus, paralysis, subarachnoid hemorrhage, tobacco misuse. Unknown: NMS, tardive dyskinesia.
Respiratory: Common: Rhinitis, increased cough, pharyngitis, dyspnea, nasopharyngitis, respiratory tract infection, sinusitis. Uncommon: Epistaxis, apnea, asthma, hemoptysis, hyperventilation, hypoxia, laryngitis, voice alteration. Rare: Lung edema, atelectasis, hiccup, hypoventilation, stridor.
Skin and appendages: Common: Sweating, acne, dry skin, fungal dermatitis, rash. Uncommon: Photosensitivity reaction, alopecia, contact dermatitis, eczema, maculopapular rash, pruritus, seborrhea, skin discoloration (e.g., hyperpigmentation), skin ulcer, urticarial, vesiculobullous rash. Rare: Hirsutism, pustular rash. Unknown: Allergic reaction (e.g., anaphylactoid reaction, angioedema, pruritus, or urticaria), eruptive xanthomas, leukocytoclastic vasculitis.
Special Senses: Common: Amblyopia, abnormal vision, blepharitis, corneal lesion. Uncommon: Abnormality of accommodation, dry eyes, cataract, deafness, diplopia, ear pain, eye hemorrhage, eye inflammation, eye pain, ocular muscle abnormality, tinnitus, taste perversion. Rare: Mydriasis, glaucoma, keratoconjunctivitis, macular hypopigmentation, miosis, pigment deposits in the eye lens.
Urogenital: Common: Urinary incontinence, urinary tract infection, dysmenorrhea, vaginitis, erectile dysfunction in males. Uncommon: Amenorrhea, breast pain, breast enlargement, galactorrhea in females, decreased or increased menstruation, menorrhagia, metrorrhagia, polyuria, urinary frequency, urinary retention, urinary urgency, impaired urination, abnormal ejaculation, cystitis, dysuria, hematuria, premenstrual syndrome, pyuria, enlarged uterine fibroids, vaginal hemorrhage, pelvic pain. Rare: Albuminuria, mastitis, oliguria. Unknown: Urinary hesitation, priapism.