Salveo

Salveo Dosage/Direction for Use

olanzapine

Manufacturer:

Amherst Lab

Distributor:

UNILAB, Inc
Full Prescribing Info
Dosage/Direction for Use
Olanzapine alone or in combination with fluoxetine is administered orally once a day, with or without food.
Schizophrenia: See Table 1.

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Prudent long-term treatment options in adult patients with schizophrenia with remitted first episodes or multiple episodes include either indefinite maintenance therapy or gradual discontinuation of the antipsychotic agent with close follow-up and a plan to reinstitute treatment upon symptom recurrence.
Discontinuance of antipsychotic therapy should be considered only after a period of at least 1 year of symptom remission or optimal response while receiving the antipsychotic agent. In patients who have had multiple previous psychotic episodes or 2 psychotic episodes within 5 years, indefinite maintenance antipsychotic treatment is recommended.
Bipolar I Disorder (Manic or Mixed Episodes): See Table 2.

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Olanzapine in Combination with Fluoxetine: See Table 3.

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Treatment Resistant Depression: See Table 4.

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Special Populations: Elderly (≥ 65 years old): Recommended Olanzapine Starting Dose: 5 mg/day.
When necessary, increase in dose should be done with caution in these patients.
Patients with Hepatic and/or Renal Impairment: Recommended Olanzapine Starting Dose: 5 mg/day.
Further dose adjustments, when indicated, should be conservative in these patients.
Smokers: The starting dose and dose range of olanzapine need not be routinely altered for non-smokers relative to smokers.
Consideration should be given to decreasing the starting dose, when more than one factor is present which might result in slower metabolism (female gender, geriatric age, non-smoking status). Dose escalation, when indicated, should be conservative in these patients.
Debilitated patients, patients with a predisposition to hypotensive reactions, patients with hepatic impairment, or patients who exhibit a combination of factors that may slow the metabolism of olanzapine or fluoxetine in combination (female gender, geriatric age, nonsmoking status), or those patients who may be pharmacodynamically sensitive to olanzapine: Recommended Olanzapine Starting Dose for Schizophrenia: 5 mg; when indicated, dose escalation should be performed with caution in these patients.
Recommended Olanzapine in Combination with Fluoxetine Starting Dose: Olanzapine 2.5 to 5 mg with fluoxetine 20 mg.
Dose modification may be necessary in patients who exhibit a combination of factors that may slow metabolism.
When indicated, dose escalation should be done with caution in these patients.
Olanzapine and fluoxetine in combination have not been systematically studied in patients over 65 years old or in patients below 10 years old.
Or, as prescribed by a physician.
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