Senna / Sennosides A & B


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Constipation As total sennosides: 15-30 mg 1-2 times/day. Bowel evacuation As sennosides: 105-157.5 mg on the day before the procedure.
Dosage Details
Oral
Constipation
Adult: 15-30 mg (as total sennosides) 1-2 times daily.
Child: 2-6 yr: 3.75-7.5 mg once daily in the morning; 6-12 yr: 7.5-15 mg once daily at night or in the morning; ≥12 yr: 15-30 mg at bedtime.

Oral
Bowel evacuation
Adult: 105-157.5 mg of sennosides on the day before the procedure. May be given as a liquid preparation.
Contraindications
Nausea or vomiting, undiagnosed abdominal pain, intestinal obstruction.
Special Precautions
Inflammatory bowel disease. Avoid prolonged use.
Adverse Reactions
Mild abdominal discomfort e.g. colic and cramps; diarrhoea, hypokalaemia and atonic non-functioning colon (prolonged use); reversible melanosis coli (chronic use). May colour the urine yellowish-brown at acidic pH or red at alkaline pH.
Action
Description: Sennosides A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified sennosides (sennosides A and B) are used similarly to senna.
Duration: 6-12 hr.
Pharmacokinetics:
Absorption: Some absorption following oral admin.
Distribution: Enters the breast milk.
Metabolism: Unabsorbed senna undergoes hydrolysis in the colon to release the active anthraquinones while absorbed senna undergoes hepatic metabolism.
Excretion: Excreted in the urine & faeces.
Disclaimer: This information is independently developed by MIMS based on Senna / Sennosides A & B from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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