Seretide

Seretide

salmeterol + fluticasone

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig
Concise Prescribing Info
Contents
100 Diskus Salmeterol xinafoate 50 mcg, fluticasone propionate 100 mcg. 250 Diskus Salmeterol xinafoate 50 mcg, fluticasone propionate 250 mcg. 500 Diskus Salmeterol xinafoate 50 mcg, fluticasone propionate 500 mcg. 25/50 MDI Salmeterol xinafoate 25 mcg, fluticasone propionate 50 mcg. 25/125 MDI Salmeterol xinafoate 25 mcg, fluticasone propionate 125 mcg. 25/250 MDI Salmeterol xinafoate 25 mcg, fluticasone propionate 250 mcg
Indications/Uses
Regular treatment of reversible obstructive airways disease (ROAD) including asthma where use of combination therapy (bronchodilator & inhaled corticosteroid) is appropriate; COPD including chronic bronchitis & emphysema.
Dosage/Direction for Use
Diskus ROAD Adult & adolescent ≥12 yr 1 inhalation of Seretide 100 or 250 or 500 bid. Childn ≥4 yr 1 inhalation of Seretide 100 bid. COPD Adult 1 inhalation of Seretide 250-500 bid. MDI ROAD Adult & adolescent ≥12 yr 2 inhalations of Seretide 25/50 or 25/125 or 25/250 bid. Childn ≥4 yr 2 inhalations of Seretide 25/50 bid. COPD Adult 2 inhalations of Seretide 25/125 or 25/250 bid.
Contraindications
Special Precautions
Not for relief of acute asthma symptoms. Consider increasing corticosteroid therapy in sudden & progressive deterioration of asthma control. Avoid abrupt w/drawal. Possible development of pneumonia in patients w/ COPD. Active or quiescent pulmonary TB, thyrotoxicosis, preexisting CV disease. Patients predisposed to low serum K levels. Systemic effects (including Cushing's syndrome, Cushingoid features, adrenal suppression, growth retardation in childn & adolescents, decrease in bone mineral density, cataract, glaucoma & central serous chorioretinopathy) may occur at high doses for prolonged periods. Monitor height of childn receiving prolonged treatment. Possibility of impaired adrenal response in patients transferring from oral steroid therapy. History of DM. Concomitant use w/ ritonavir, ketoconazole & other strong CYP3A4 inhibitors. Discontinue use if paradoxical bronchospasm occurs. Pregnancy & lactation. Childn <4 yr.
Adverse Reactions
Headache. Mouth & throat candidiasis, pneumonia (in COPD patients); hoarseness/dysphonia; muscle cramps, arthralgia.
Drug Interactions
Avoid use w/ non-selective & selective β-blockers. Increased plasma conc w/ ritonavir. Increased systemic exposure w/ ketoconazole.
ATC Classification
R03AK06 - salmeterol and fluticasone ; Belongs to the class of adrenergics in combination with corticosteroids or other drugs, excluding anticholinergics. Used in the treatment of obstructive airway diseases.
Presentation/Packing
Form
Seretide 100 Diskus
Packing/Price
60 dose x 1's
Form
Seretide 250 Diskus
Packing/Price
60 dose x 1's
Form
Seretide 500 Diskus
Packing/Price
60 dose x 1's
Form
Seretide 25/125 MDI
Packing/Price
120 dose x 1's;60 dose x 1's
Form
Seretide 25/250 MDI
Packing/Price
120 dose x 1's;60 dose x 1's
Form
Seretide 25/50 MDI
Packing/Price
120 dose x 1's;60 dose x 1's
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