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If allergic reactions occur, the infusion should be stopped immediately. If allergic reactions persist, then appropriate treatment is recommended. In anaphylactic reactions, treatment should follow the current recommendations for shock therapy.
The colloid-osmotic effect of human albumin 20% Is approximately four times that of blood plasma.
Therefore, when concentrated albumin is administered, care must be taken to assure adequate hydration of the patient. Patients should be monitored carefully to guard against circulatory overload and hyperhydration.
If the required volume of Human Albumin 20% exceeds 200 mL, appropriate additional electrolyte solutions should be administered to maintain normal fluid balance.
Alternatively, therapy may be continued with 5% human albumin solution.
If comparatively large volumes are to be replaced, controls of coagulation and haematocrit are necessary. Care should be taken to ensure adequate substitution of other blood constituents (coagulation factors, electrolytes, platelets and erythrocytes).
If haematocrit drops below 30%, packed red cells should be given in order to maintain the oxygen transport capacity of the blood.
Effects on the ability to drive and use machines: There are no indications that human albumin may impair the ability to drive or use machines.
