Dose range: 5-80 mg/day. Starting dose: 20-40 mg once daily in the evening. Reductions in risk of CHD mortality & CV events
40 mg/day. Patient w/ homozygous familial hypercholesterolemia
40 mg/day in the evening or 80 mg/day in 3 divided doses of 20 mg, 20 mg & an evening dose of 40 mg. Patient w/ heterozygous familial hypercholesterolemia Adolescent 10-17 yr
Start on 10 mg once daily in the evening. Recommended dosing range is 10-40 mg/day. Max: 40 mg/day. Adjust the dose at intervals of ≥4 wk. Concomitant lipid-lowering therapy
Max: 10 mg/day. Patient taking cyclosporine or danazol
Start w/ 5 mg/day. Max: 10 mg/day. Patient taking amiodarone or verapamil
Max: 20 mg/day. Patient w/ renal insufficiency
Start at 5 mg/day.