The most frequent adverse reactions of oral Salbutamol include tremors (particularly of the hands), nervousness, headache, dizziness, sleeplessness or insomnia, weakness, drowsiness, restlessness, irritability, tachycardia, palpitation, peripheral vasodilation, flushing, chest discomfort, nausea, dyspepsia, difficulty in micturition, and rarely muscle cramps.
Erythema multiforme or Stevens-Johnson syndrome has been reported rarely with administration of oral Salbutamol in children.
Potentially serious hypokalemia has also been reported.
Hypersensitivity reactions (including urticaria, angioedema, rash, paradoxical bronchospasm, anaphylaxis, oropharyngeal edema, and collapse) and arrhythmias (including atrial fibrillation, supraventricular tachycardia, and extrasystoles) have also been observed with the use of Salbutamol.
Salbutamol, like other sympathomimetic agents, can cause vertigo, central nervous system stimulation, angina, hypertension, unusual taste, and drying or irritation of the oropharynx.
Carbocisteine is generally safe. The most common adverse effects include nausea, headache, gastric discomfort, and diarrhea. Gastrointestinal bleeding and skin rash has occasionally occurred. Other isolated reports include dizziness, insomnia, myalgia, dyspnea, palpitations, urinary incontinence, mild hypoglycemia, dry mouth, flatulence, atrial fibrillation, and minor psychiatric disturbance.