Corticosteroids or corticotrophin. May increase renal clearance of acidic products eg, tetracyclines especially doxycycline, acetylsalicylic acid, chlorpropramide, lithium, methenamine & increase t½
& duration of action of basic drugs eg, quinidine, amphetamines, ephedrine, pseudoephedrine, memantine & flecainide. May increase renal tubular reabsorption of mecamylamine. Hypochloraemic alkalosis may occur w/ K-depleting diuretics eg, bumetanide, ethacrynic acid, furosemide & thiazides. May reduce serum K conc of K supplements.