Each mL contains: Dicycloverine hydrochloride 5 mg.
Pharmacology: Pharmacokinetics: Dicycloverine is readily absorbed from the gastrointestinal tract, it is also absorbed from mucus membranes, the eye, and to some extent through intact skin. It is rapidly cleared from the blood and is distributed throughout the body. It crosses the blood-brain barrier. It is incompletely metabolized in the liver and is excreted in the urine as unchanged drug and metabolites. A half-life of about 4 hours has been reported.
Used in the symptomatic, relief of gastrointestinal spasm particularly that associated with the irritable bowel syndrome and as adjunct in the treatment of peptic ulcer.
Children 6 months to 2 years: 1 mL-2 mL three to four times daily, doses are usually given 15 minutes before meals.
It should be used with caution in children who may be more susceptible to its adverse effects. Caution is generally advisable in patients with diarrhea. It should not be given to patients with angle-closure glaucoma or with a narrow angle between the iris and cornea, since it may raise intraocular pressure. It should not be given to infant younger than 6 months of age.
Adverse effects include dryness of the mouth with difficulty in swallowing and talking, thirst, reduced bronchial secretions, dilation of the pupils (mydriasis) with loss of accommodation (cycloplegia) and photophobia, flushing and dryness of the skin, transient bradycardia, with palpitations and arrhythmias, and difficulty in micturition, as well as reduction in the tone and motility of the gastrointestinal tract leading to constipation.
Store at temperatures not exceeding 30°C.
A03AA07 - dicycloverine ; Belongs to the class of synthetic anticholinergics, esters with tertiary amino group. Used in the treatment of functional bowel disorders.
Oral drops 5 mg/mL x 15 mL.