Spiva with MCT-LCT

Spiva with MCT-LCT



Claris Lifesciences


Macropharma Corp
Concise Prescribing Info
Induction & maintenance of general anesth. Sedation in adult patients undergoing diagnostic procedures or surgery in conjunction w/ local or regional anesth & in ventilated adult patients under intensive care.
Dosage/Direction for Use
IV General anesth induction Titrate 20-40 mg every 10 sec. Adult <55 yr 1.5-2.5 mg/kg. Elderly, patient of ASA grade III & IV especially those w/ impaired cardiac function 1 mg/kg. Maintenance: Increments of 25-50 mg by repeated bolus inj or 4-18 mg/kg/hr by continuous infusion. Childn >1 mth 2.5 mg/kg. Maintenance: 9-15 mg/kg/hr by continuous infusion. Duration of use: Childn <3 yr 20 min. Max: 75 min. Adult Sedation during intensive care 0.3-4 mg/kg/hr by continuous infusion. Sedation for diagnostic & surgical procedure 0.5-1 mg/kg over 1-5 min. Maintenance: 1.5-4.5 mg/kg/hr infusion. May be supplemented by 10-20 mg bolus inj.
Infant <1 mth for induction & maintenance of anesth. Childn & adolescents ≤16 yr for sedation in intensive care.
Special Precautions
Cardiac, resp, kidney or liver disease; hypovolemic, debilitated or epileptic patients; ophth surgery; electroconvulsive therapy; severe cardiac impairment; high intracranial pressure & low arterial pressure; hereditary acute porphyria; obese & those receiving TPN. Consider IV administration of anticholinergic agent before induction or during maintenance of anesth in increased risk of relative vagotonia. Disorders of fat metabolism or diseases requiring restrictive use of lipid emulsions. Monitor lipids in ICU treatment after 3 days. May impair ability to drive or operate machinery. Pregnancy & lactation. Infants & childn up to 5 yr.
Adverse Reactions
Hypotension, transient apnea; coughing; pulmonary edema, asystole, bradycardia, convulsions.
Drug Interactions
Benzodiazepines, parasympatholytic agents, inhalation anesth; opioids; suxamethonium, neostigmine, CNS depressants eg, alcohol, general anesth, narcotic analgesics; fentanyl; cyclosporine.
MIMS Class
Anaesthetics - Local & General
ATC Classification
N01AX10 - propofol ; Belongs to the class of other general anesthetics.
Spiva with MCT-LCT emulsion for infusion 10 mg/mL
20 mL x 1's
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