Interferes w/ the anti-platelet effect of low-dose aspirin. Displaces warfarin from protein-binding sites & may enhance response to oral anticoagulants. Reduced efficacy of diuretics & other antihypertensive drugs, including ACE inhibitors, angiotensin II antagonist & β-blockers. Increased risk of GI ulceration or bleeding w/ corticosteroids. May increase risk of nephrotoxicity w/ cyclosporine & tacrolimus. Changes in the effects of oral hypoglycemic agents. Elevation of plasma lithium & reduction in renal lithium clearance. Increased plasma levels of methotrexate.