mefenamic acid




Metro Drug
Concise Prescribing Info
Mefenamic acid
Relief of mild to moderate pain arising from RA (including Still's disease), soft tissue injuries, other painful musculoskeletal conditions, headache, dental pain, post-op pain & dysmenorrhea.
Dosage/Direction for Use
Adult & childn >12 yr Initially 1 tab followed by ½ tab every 8 hr as needed. Not to be given >7 days.
Should be taken with food: Take w/ or immediately after meals.
Hypersensitivity. Patients who have history of stroke, CVA, heart attack, MI, CABG, uncontrolled HTN & CHF (NYHA II-IV). Active peptic ulcer or inflammatory bowel disease. Hepatic & renal impairment. Cross-sensitivity w/ aspirin & other NSAIDs.
Special Precautions
Impaired renal & liver function. Avoid prolonged treatment for >7 days. Concomitant w/ plasma-protein-binding drugs & anticoagulants. Discontinue treatment if skin rash, diarrhea or other significant GI discomfort occurs. Not recommended during pregnancy & lactation. Not recommended in childn.
Adverse Reactions
Dyspepsia, upper GI discomfort, diarrhea or constipation & abdominal pain. Allergic glomerulonephritis; hemolytic anemia, agranulocytosis, pancytopenia, thrombocytopenia or thrombocytopenic purpura & bone marrow aplasia (on long-term treatment).
Drug Interactions
Interferes w/ the anti-platelet effect of low-dose aspirin. Displaces warfarin from protein-binding sites & may enhance response to oral anticoagulants. Reduced efficacy of diuretics & other antihypertensive drugs, including ACE inhibitors, angiotensin II antagonist & β-blockers. Increased risk of GI ulceration or bleeding w/ corticosteroids. May increase risk of nephrotoxicity w/ cyclosporine & tacrolimus. Changes in the effects of oral hypoglycemic agents. Elevation of plasma lithium & reduction in renal lithium clearance. Increased plasma levels of methotrexate.
ATC Classification
M01AG01 - mefenamic acid ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, fenamates.
Stangesic FC tab 500 mg
100's (P5.55/film-coated tab)
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