Initial Dose: 15-60 mg daily. It is usually given in 3 divided doses but single daily dose is also possible. Improvement is usually seen in 1-3 weeks and control of symptoms is 1-2 months.
Euthyroid Patient: Dose is gradually reduced to a maintenance dose, usually 5-15 mg daily. Alternatively, the dose may be continued at the initial level with supplemental levothyroxine as a blocking-replacement regimen either form of maintenance treatment usually continued for 1-2 years.
Children: Initial Dose: 400 mcg/kg in divided doses; for maintenance this dose may be halved.