Aspirin: Concomitant administration of Diclofenac & Aspirin is not recommended.
Anticoagulants: Caution should be exercised while administering anticoagulants with Diclofenac since interactions of anticoagulants have been seen with other NSAIDs. Digoxin, Methotrexate, Cyclosporine.
Lithium: Patients who begin taking diclofenac or who increase their diclofenac dose while taking these drugs should be observed closely, particularly if renal functions are impaired. In case of digoxin, serum level should be maintained.
Oral Hypoglycemic: Isolated cases have been reported of hypoglycemic and hyperglycemic reactions necessitating an adjustment in the dosage of antidiabetic drugs treatment with diclofenac.
Diuretics: Concomitant treatment of diclofenac with potassium-sparing diuretics may raise serum potassium levels, which should therefore be monitored.