Concise Prescribing Info
Contents
Per 250 mg/125 mg Ampicillin Na 250 mg, sulbactam Na 125 mg. Per 500 mg/250 mg Ampicillin Na 500 mg, sulbactam Na 250 mg. Per 1 g/500 mg Ampicillin Na 1 g, sulbactam Na 500 mg
Indications/Uses
Infections due to β lactamase-producing organisms eg, upper & lower resp tract infections including sinusitis, otitis media & epiglottitis; bacterial pneumonia; UTI & pyelonephritis; intra-abdominal infections including peritonitis, cholecystitis, endometritis & pelvic cellulitis; bacterial septicemia; skin, soft tissue, bone & joint, & gonococcal infections. May be administered peri-op to reduce incidence of post-op wound infections in abdominal or pelvic surgery. Prophylaxis to reduce post-op sepsis in termination of pregnancy or caesarian section.
Dosage/Direction for Use
IV/IM 1.5-12 g/day in divided doses. Mild infections 1.5-3 g. Moderate infections Up to 6 g. Severe infections Up to 12 g. Neonate 150 mg/kg/day.
Contraindications
Special Precautions
Should not be administered to patients w/ infectious mononucleosis. Serious anaphylactic reactions. Discontinue use if allergic reactions or superinfection occur. Check periodically for organ system (renal, hepatic & hematopoietic) dysfunction during extended therapy. Pregnancy & lactation. Neonates especially when premature & other infants.
Adverse Reactions
Inj site pain (IM), phlebitis (IV). Nausea, vomiting & diarrhea; rash, itching & other skin reactions; anemia, thrombocytopenia, eosinophilia & leukopenia; transient elevations of ALT & AST.
Drug Interactions
Prolonged t½ w/ probenecid. Ampicillin: Increased frequency of skin rashes w/ allopurinol. Reduced absorption w/ chloroquine. Possibility of prolonged bleeding time w/ anticoagulants.
MIMS Class
Penicillins
ATC Classification
J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Sulbacin 1 g/500 mg powd for inj
Packing/Price
10 × 1's
Form
Sulbacin 250 mg/125 mg powd for inj
Packing/Price
10 × 1's;1's
Form
Sulbacin 500 mg/250 mg powd for inj
Packing/Price
10 × 1's
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