As with other parenteral antibiotics, the principal side effects observed is injection site pain, especially associated with the intramuscularly route of administration. A small number of patients may develop phlebitis after intravenous administration.
Gastro-intestinal: the most common are nausea, vomiting and diarrhea.
Skin/skin structure: the most common are rash, itching and other skin reactions.
Hematopoietic and Lymphatic system: anemia, thrombocytopenia, eosinophilia and leukopenia have been reported during therapy with Ampicillin/Sulbactam sodium. These reactions are reversible on discontinuation of therapy and believed to be hypersensitivity reactions.
Hepatic: transient elevations of alanine and aspartic transaminases have been observed.
It is expected that the adverse reaction associated with the use of ampicillin will be occasionally observed.