Ampicillin/Sulbactam I.M/I.V. is indicated for infections where beta-lactamase production is suspected. Typical indications are upper and lower respiratory tract infections including sinusitis, otitis media and epiglottitis; bacterial pneumonia; urinary tract infections and pyelonephritis; intra-abdominal infections including peritonitis, cholecystitis, endometritis and pelvic cellulitis; bacterial septicemia; skin; soft tissue, bone and joint infection and gonococcal infections.
Ampicillin/Sulbactam I.M/I.V may also be administered peri-operatively to reduce the incidence of post-operative wound infections in patients undergoing abdominal or pelvic surgery, in which peritoneal contamination may be present. In termination of pregnancy or caesarian section, Ampicillin/Sulbactam may be used as prophylaxis to reduce postoperative sepsis.
Since infection mononucleosis is viral in origin, Ampicillin should not be used in the treatment. A high percentage of patients with mononucleosis who receive Ampicillin develop a skin rash.