Sulbacin Mechanism of Action

ampicillin + sulbactam


Singapore Pharmawealth Lifesciences


Phil Pharmawealth


Phil Pharmawealth
Full Prescribing Info
Pharmacology: Pharmacokinetics: Approximately 80% of an intramuscular or intravenous dose of 500 mg is eliminated in the urine in this time. Severe renal impairment markedly prolongs the persistence of the drug in the plasma. Peritoneal dialysis is ineffective in removing the drug from the blood, but the hemodialysis removes about 40% of the body store in about 7 hours. Adjustment of the dose is required in the presence of renal dysfunction.
Microbiology: Action: Sulbactam sodium has a greater activity against Type 1 β-lactamases than clavulanate, but does not penetrate the cell walls of Gram-negative bacteria as well. It extends the antibacterial spectrum of Ampicillin to include β-lactamase-producing strains of Acinetobacter, Bacteroides and other anaerobes, Branhamella, Enterobacter, E. coli, Neisseria, Klebsiella, Proteus, Staphylococcus. It has a weak antibacterial activity of its own.
Ampicillin is an alternative drug against Klebsiella pneumoniae (with Sulbactam), indole-positive Proteus (M. morganii, P. vulgaris and P. rettgeri; with Sulbactam), Salmonella typhi, Shigella, Gardnerella vaginalis, H. influenzae or Nocardia. Some of these readily acquire resistance by elaboration of penicillinase, so it is given often in combination with Sulbactam.
Sulbactam, a broad spectrum antibiotic and Ampicillin, a β-lactamase inhibitor is effective against selected Gram-positive, Gram-negative, and anaerobic organisms. High concentrations of Sulbactam and Ampicillin are achieved in the blood following intravenous or intramuscular administration and both components have a half-life of approximately one hour. Most of the Ampicillin/Sulbactam is excreted unchanged in the urine.
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