Each Film-Coated tablet contains: Sultamicillin (as tosylate) 375 mg.
Sultamicillin (as tosylate) 750 mg.
Sultamicillin is a prodrug ampicillin and the beta-lactamase inhibitor sulbactam; it consists of the two compounds linked chemically as a double ester. During absorption from the gastrointestinal tract it is hydrolyzed, releasing equimolar quantities of ampicillin and sulbactam.
Pharmacology: Pharmacokinetics: The pharmacokinetics of ampicillin and sulbactam are broadly similar and neither appears to affect the other to any great extent.
Microbiology: Antimicrobial Action: There is synergy against some beta-lactamase-producing organisms between ampicillin and sulbactam. Various effects ranging from synergy to antagonism have been reported.
Sultamicillin is used in the treatment of infections where beta-lactamase-producing organisms might occur, including uncomplicated gonorrhea, otitis media, respiratory tract and urinary tract infections.
The usual dose is 375 mg to 750 mg twice daily or as prescribed by the physician.
Patients known to be hypersensitive to penicillin should be given an antibacterial of another class. Care is necessary if very high doses are given, especially if renal function is poor.
The most common adverse effects are hypersensitivity reactions, especially skin rashes; anaphylaxis occasionally occurs and has sometimes been fatal.
Store at temperatures not exceeding 30°C.
J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
FC tab 375 mg x 50's. 750 mg x 50's.
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