CV diseases (eg, CHD, Prinzmetal's angina & cardiac failure) & hypotension. Patients w/ 1st degree heart block, severe peripheral circulatory disturbance/disorders (ie, severe forms of Raynaud's disease or syndrome), mild/moderate COPD, subject to spontaneous hypoglycaemia or w/ labile diabetes, angle-closure glaucoma, history of atopy or severe anaphylactic reaction. May mask signs of hyperthyroidism. Choroidal detachment. May block systemic β-agonist effect eg, adrenaline. Possibility of eyelash growth, darkening of eyelid skin & increased iris pigmentation. Aphakic or pseudophakic patients w/ torn posterior lens capsule or anterior chamber lenses, or in patients w/ known risk factors for cystoid macular oedema or iritis/uveitis. Childn & adolescent <18 yr. Do not use during pregnancy & lactation.
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