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4 mg: Licensed product information recommends caution when potent inducers of the cytochrome P450 isoenzyme CYP3A4 such as phenytoin, phenobarbital, or rifampicin are given with montelukast.
Corticosteroids: For a report of peripheral oedema in a patient given montelukast and prednisone.
Phenobarbital: Peak serum concentrations after a single dose of montelukast 10 mg were reduced by 20% in 14 healthy subjects who tool phenobarbital 100 mg daily for 14 days, and area under the serum concentration-time curve was reduced by 38%. However, it was not thought that montelukast doses would need adjustment if given with phenobarbital.
