antithymocyte immunoglobulin, equine






BSV Bioscience Phils
Concise Prescribing Info
Antithymocyte immunoglobulin (equine)
Management of allograft rejection, including delay of onset of 1st rejection episode in patients who have undergone renal transplantation. Adjunct w/ conventional therapy to delay onset of 1st rejection episode. Moderate to severe aplastic anemia in patients not suitable for bone marrow transplant.
Dosage/Direction for Use
Renal allograft Adult 10-30 mg/kg or 10-15 mg/kg daily for 14 days (14 doses) followed by alternate day therapy for further 14 days (7 doses). Bringing the total doses to 21-28 days. Childn 5-25 mg/kg daily. When given to delay onset of 1st rejection episode, start therapy w/in 24 hr before or after transplant. When given to treat rejection, start therapy at the time of diagnosis of the 1st rejection episode. Aplastic Anemia 10-20 mg/kg daily for 8-14 days followed by alternate day therapy for a total of 21 doses.
Previous history of severe systemic reaction to Thymogam or any other equine globulin prep.
Special Precautions
Discontinue therapy if anaphylaxis or severe & unremitting thrombocytopenia or leucopenia occurs. Possibility of transmission of some infectious diseases may occur; cytomegalovirus infection. Recommend skin testing prior commencing treatment for those at greatest risk of systemic anaphylaxis. Monitor patients carefully for concurrent infections. Pregnancy & lactation.
Adverse Reactions
Fever, chills, leucopenia, thrombocytopenia, arthralgia, dermatologic reactions eg, rash, urticaria, wheal, flare & pruritus. Abnormal liver & renal function tests, serum sickness; headache, nausea, vomiting, diarrhea, dyspnea, hypotension, night sweats, stomatitis, chest pain, back pain, pain at the infusion site, clotted A/V fistula & peripheral thrombophlebitis.
Drug Interactions
Corticosteroids & other immunosuppressants.
MIMS Class
ATC Classification
L04AA04 - antithymocyte immunoglobulin (rabbit) ; Belongs to the class of selective immunosuppressive agents. Used to induce immunosuppression.
Thymogam soln for IV infusion 50 mg/mL
5 mL x 1's
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