Topamax

Topamax

topiramate

Manufacturer:

Johnson & Johnson

Distributor:

Zuellig
Concise Prescribing Info
Contents
Topiramate
Indications/Uses
Monotherapy in patients w/ newly diagnosed epilepsy or for conversion to monotherapy in patients w/ epilepsy. Adjunctive therapy in patients w/ partial-onset seizures or generalized tonic clonic seizures & seizures associated w/ Lennox-Gastaut syndrome. Prophylaxis of migraine headache.
Dosage/Direction for Use
Monotherapy Adult Initially 25 mg nightly for 1 wk, then should be increased at 1-2 wk intervals by increments of 25 or 50 mg/day in 2 divided doses. Recommended dose: 100-500 mg/day. Some patient w/ refractory forms of epilepsy have tolerated topiramate monotherapy at doses of 1,000 mg/day. Dosing recommendations applicable to all adults including the elderly in the absence of underlying renal disease. Childn ≥2 yr Initially 0.5-1 mg/kg nightly for the 1st wk, then should be increased at 1-2 wk intervals by increments of 0.5-1 mg/kg/day in 2 divided doses. Recommended dose: 100-400 mg/day. Childn w/ recently diagnosed partial onset seizures have received doses of up to 500 mg/day. Adjunctive therapy Adult Same as monotherapy. Usual daily dose: 200-400 mg in 2 divided doses. Childn >2 yr Begin at 25 mg (or less) nightly for 1st wk, then dose should be increased at 1-2 wk intervals by increments of 1-3 mg/kg/day in 2 divided doses. Recommended total daily dose: 5-9 mg/kg/day in 2 divided doses. Daily doses up to 30 mg/kg/day have been studied & were generally well tolerated. Migraine Titrate initially w/ 25 mg every night for 1 wk. Increase by 25 mg/day at 1-wk interval. Use longer intervals between dose adjustment if patient cannot tolerate titration schedule. Prevention of migraine 100 mg/day in 2 doses. Total daily dose 50-200 mg/day depending on patient response. Dosage rate & titration should be clinically monitored.
Administration
May be taken with or without food: Swallow whole, do not chew/crush.
Contraindications
Special Precautions
Gradual w/drawal. Renal impairment. Proper hydration; hepatically impaired patients; acute myopia & secondary angle closure glaucoma; nutritional supplementation. Increased incidence of mood disturbances, depression & suicidal attempt. May impair ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Ataxia, impaired conc, dizziness, mood problems, diplopia, increased salivary flow. Less commonly, cognitive problems, apathy, aphasia, emotional lability, nystagmus, taste perversion.
Drug Interactions
Phenytoin, carbamazepine. Valproic acid, phenobarb, primidone, agents predisposing nephrolithiasis. Lithium, glyburide.
ATC Classification
N03AX11 - topiramate ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Topamax tab 50 mg
Packing/Price
60's (P4,411/pack)
Form
Topamax tab 25 mg
Packing/Price
60's (P2,212/pack)
Form
Topamax tab 100 mg
Packing/Price
60's (P8,842/pack)
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