Periodic monitoring of serum K & creatinine levels in patients w/ renal impairment; assessment of renal function, especially in elderly ≥75 yr & w/ impaired renal function in patients w/ heart failure. Monitor BP in patients on hemodialysis. Concomitant therapy w/ ACE inhibitors in heart failure. May increase blood urea & serum creatinine in patients w/ bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Kidney transplantation. Hypotension during anesth & surgery. Aortic or mitral valve stenosis, or obstructive hypertrophic cardiomyopathy. Not recommended in primary hyperaldosteronism. Concomitant use w/ K-sparing diuretics, K supplements, salt substitutes containing K, & heparin. Hyperkalemia. Excessive BP decrease in patients w/ ischemic cardiopathy & cerebrovascular disease could result in MI or stroke. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive or operate machinery. Childn <18 yr.