Toujeo Drug Interactions

insulin glargine




Full Prescribing Info
Drug Interactions
Tell the doctor, pharmacist or nurse if the patient is taking, had recently taken or might take any other medicines.
Some medicines can change the blood sugar level. This may mean the insulin dose has to change. So, before taking a medicine ask the doctor if it will affect the blood sugar and what action, if any, the patient needs to take. The patient also needs to be careful when stopping taking a medicine.
The blood sugar level may fall (hypoglycaemia) if the patient takes: Any other medicine to treat diabetes. Disopyramide - for some heart problems. Fluoxetine - for depression. Sulfonamide antibiotics. Fibrates - for lowering high levels of blood fats. Monoamine oxidase inhibitors (MAOIs) - for depression. Angiotensin converting enzyme (ACE) inhibitors - for heart problems or high blood pressure. Medicines to relieve pain and lower fever, such as pentoxifylline, propoxyphene and salicylates (such as acetylsalicylic acid).
Pentamidine - for some infections caused by parasites. This may cause too low blood sugar which is sometimes followed by too high blood sugar.
The blood sugar level may rise (hyperglycaemia) if the patient takes: Corticosteroids such as cortisone - for inflammation. Danazol - for endometriosis. Diazoxide - for high blood pressure. Protease inhibitors - for HIV. Diuretics - for high blood pressure or fluid retention. Glucagon - for very low blood sugar. Isoniazid - for tuberculosis. Somatropin - a growth hormone. Thyroid hormones - for thyroid gland problems. Oestrogens and progestogens - such as in the contraceptive pill for birth control. Clozapine, olanzapine and phenothiazine derivatives - for mental health problems. Sympathomimetic medicines such as epinephrine (adrenaline), salbutamol and terbutaline - for asthma.
The blood sugar level may either rise or fall if the patient takes: Beta-blockers or clonidine - for high blood pressure. Lithium salts - for mental health problems.
Beta-Blockers: Beta-blockers like other "Sympatholytic medicines" (such as clonidine, guanethidine, reserpine - for high blood pressure) may make it harder to recognise warning signs of the blood sugar being too low (hypoglycaemia). It can even hide or stop the first signs that the blood sugar is too low.
Pioglitazone Used Together with Insulin: Some patients with long-standing type 2 diabetes mellitus and heart disease or previous stroke who were treated with pioglitazone and insulin experienced the development of heart failure. If the patient experiences signs of heart failure such as unusual shortness of breath, a rapid increase in weight or localised swelling (oedema). Inform the doctor as soon as possible.
If any of the previously mentioned apply to the patient (or the patient is not sure), talk to the doctor, pharmacist or nurse before using Toujeo.
Toujeo with Alcohol: The blood sugar level may either rise or fall if the patient drinks alcohol. Check the patient's blood sugar level more than usual.
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