The recommended standard dosage is 15-25 mg/kg bodyweight (i.e. 2-3 tablets) two to three times daily. For the indications listed as follows the following doses may be used.
Prophylaxis and treatment of haemorrhage in high risk patients should commence pre- or post-operatively; thereafter 2 tablets three to four times daily until macroscopic haematuria is no longer present.
Recommended dosage is 2 tablets 3 times daily as long as needed for up to 4 days. If very heavy menstrual bleeding, dosage may be increased. A total dose of 4 g daily (8 tablets) should not be exceeded. Treatment with Tranexamic Acid (Transtat) Film-coated tablets should not be initiated until menstrual bleeding has started.
Where recurrent bleeding is anticipated oral therapy (2 tablets three times daily) should be administered for 7 days.
Conisation of the cervix:
3 tablets three times daily.
2-3 tablets three times daily. The dose is based on 25 mg/kg three times a day.
Hereditary angioneurotic oedema:
Some patients are aware of the onset of the illness; suitable treatment for these patients is intermittently 2-3 tablets two to three times daily for some days. Other patients are treated continuously at this dosage.
In the management of dental extractions 2-3 tablets every eight hours. The dose is based on 25 mg/kg.
By extrapolation from clearance data relating to the intravenous dosage form, the following reduction in the oral dosage is recommended for patients with mild to moderate renal insufficiency. (See table.)
Click on icon to see table/diagram/image
This should be calculated according to body weight at 25 mg/kg per dose. However, data on efficacy, posology and safety for these indications are limited.
No reduction in dosage is necessary unless there is evidence of renal failure.
Method of administration: