Hypersensitivity to tramadol, paracetamol or to any of the excipients of the medicinal product.
Acute intoxication with alcohol, hypnotic drugs, centrally-acting analgesics, opioids or psychotropic drugs.
Tramadol Hydrochloride & Paracetamol tablets should not be administered to patients who are receiving monoamine oxidase inhibitors or within two weeks of their withdrawal.
Severe hepatic impairment.
Epilepsy not controlled by treatment.