Sterile Ceftriaxone Sodium can be given IM or IV, in the seriously ill patient the IV route is preferred. The usual duration of therapy is 4 to 14 days; in complicated infections, longer therapy may be required.
Children: The usual dosage of Sterile Ceftriaxone for the serious infections in children and other than CNS infections (meningitis) caused by susceptible organisms is 50-75 mg/kg (not to exceed 2 g) daily in equally divided doses every 12 hours or in single daily doses.
For the treatment of CNS infections, the usual dosage is 100 mg/kg given in equally divided doses every 12 hours or 75 mg/kg loading dose of a drug maybe used to initiate therapy.
Dosage in renal and hepatic impairment: Sterile Ceftriaxone Sodium is executed via both biliary and renal excretion. Therefore, patients with renal failure normally require no adjustment in dosage when usual doses of Sterile Ceftriaxone Sodium are administered, but concentrations of drug in serum should be monitored periodically. Dosage adjustments should not be necessary in patients with hepatic dysfunction; however in patients with both hepatic dysfunction and significant renal diseases, Sterile Ceftriaxone Sodium should not exceed 2 g daily.
Adults: The usual adult dose is 1 to 2 g daily as a single dose or in two divided doses. In severe infections up to 4 g daily. For the treatment of gonorrhea, a single intramuscular dose of 250 mg is recommended. For surgical infection prophylaxis in adults, a single dose of 1 g is administered 0.5 to 2 hours prior to surgery or as directed by a physician.