Each vial contains: Ceftriaxone (as sodium) 1 g.
Trizone, the brand of Ceftriaxone, is long acting, broad-spectrum Cephalosporin antibiotic.
The bacterial activity of Ceftriaxone results from inhibition of cell wall synthesis. Ceftriaxone exerts in vitro activity against a wide range of gram-negative and gram-positive microorganisms. Ceftriaxone is highly stable to most β-lactamase, both Penicillinases, of gram-positive and gram-negative bacteria.
Treatment lower respiratory tract infections, skin and skin structure infections, bone and joint infections, intra-abdominal and urinary tract infections, sepsis and meningitis due to susceptible organism; documented or suspected infection due to susceptible organism in home care patients at high risk for bacteremia, periorbital or buccal cellulities, salmonellosis or shigellosis, and pneumonia of unestablished etiology (<5 years of age).
Adults and children over 12 years: The usual dosage is 1-2 g once daily. In severe cases, the dosage may be raised to 4 g once daily.
Neonates: A daily dose of 20-50 mg/kg body weight.
Infants and children up to 12 years: A daily dose of 20-80 mg/kg.
Impaired renal and liver function: Only in cases of preterminal renal failure (creatinine clearance <10 mL/min.) should the Ceftriaxone (Trizone) dosage not exceed 2g daily. In cases of concomitant severe renal and hepatic dysfunction, the plasma concentration of Ceftriaxone (Trizone) should be determined at regular intervals.
Administration of Ceftriaxone (Trizone) should be continued for a minimum of 48-72 hours.
Synergy between Ceftriaxone (Trizone) and Aminoglycosides has been demonstrated with gram-negative bacilli. Because of physical incompatibility the two drugs must be given separately at the recommended dosages.
Ceftriaxone (Trizone) is contraindicated in patients with known hypersensitivity to the cephalosporins. The possibility of allergic cross-reactions should be borne in mind patients hypersensitive to Penicillins.
Anaphylactic shock requires immediate counter-measures such as I.V. epinephrine followed by a glucocorticoid.
Use in Pregnancy: Ceftriaxone (Trizone) should not be given in pregnancy unless absolutely indicated.
Use in Pregnancy: Ceftriaxone (Trizone) should not be given in pregnancy unless absolutely indicated.
Gastrointestinal: diarrhea, vomiting, nausea and stomatitis.
Hematologic: eosinophilia, leukopenia, granulocytopenia.
Dermatological: allergic dermatitis, pruritus, edema, urticaria.
Other rare side effects: headache, dizziness, increase in liver enzymes and serum creatinine and anaphylactoid reactions.
Direction for use: Dissolve the content in sterile water for injection.
I.V. injection: Trizone 1 g is dissolved in 10 mL, of sterile water for injection lasting 2-4 minutes.
I.M. injection: Trizone 1 g is dissolved in 4 mL, of sterile water for injection, lasting 2-4 minutes.
Discard any unused portion.
Store at temperatures not exceeding 25°C. Protect from light and moisture.
J01DD04 - ceftriaxone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Powd for inj (vial) 1 g x 1's, 50's.
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