General Dosing Recommendations: Individualize dosage according to patient's clinical response.
Taking cilostazol with food increases the maximum cilostazol plasma concentrations, which may be associated with increased incidence of adverse effects.
Patients may respond as early as 2 to 4 weeks after the initiation of therapy, but treatment for up to 12 weeks may be needed before a beneficial effect is experienced.
Recommended Oral Adult Dose: 100 mg twice daily, taken at least half an hour before or two hours after breakfast and dinner.
Coadministration with Cytochrome Inhibitors* (see Interactions): 50 mg twice daily.
*CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, clarithromycin diltiazem).
*CYP2C19 inhibitors (e.g., omeprazole).
Discontinuation of Therapy: Available data suggest that cilostazol dosage can be reduced or discontinued without rebound platelet hyperaggregability.