Known hypersensitivity to atropine or other anticholinergic agents. Patients with obstructive disease of the gastrointestinal tract (e.g. pyloroduodenal stenosis), cardiospasm, paralytic ileus or intestinal atony (especially in geriatric or debilitated patients). Megacolon complicating ulcerative colitis. Prostatic enlargement. Unstable cardiovascular status in acute haemorrhage. Tachycardia secondary to cardiac insufficiency of thyrotoxicosis. Toxaemia of pregnancy.
It is also contraindicated in patients with obstructive uropathy (e.g. bladder neck obstruction caused by prostatic hypertrophy). Due to risk of provoking hyperpyrexia, atropine should not be given to patients, especially children, where the ambient temperature is high.
Atropine should not be given to patients with closed angle glaucoma.