Trucox

Trucox Mechanism of Action

celecoxib

Manufacturer:

Flamingo

Distributor:

Trumed

Marketer:

Hexagon Pharma
Full Prescribing Info
Action
Pharmacology: Pharmacodynamics: Mechanism of Action: Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities. The mechanism of action of celecoxib is believed to be due to the inhibition of prostaglandin synthesis, primarily via the inhibition of cyclo-oxygenase-2 and the therapeutic concentrations in humans. Celecoxib does not inhibit the cyclo-oxygenase-1 isoenzyme.
Pharmacokinetics: Absorption: Peak plasma levels of celecoxib occur approximately 3 hours after an oral dose. Under fasting conditions, both peak plasma levels (Cmax) and area under the curve (AUC) are roughly dose proportional up to 200 mg twice a day; at higher doses, there are less than proportional increases in Cmax and AUC.
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