May decrease efficacy w/ drugs for infection (eg, ampicillin, chloramphenicol, neomycin, penicillin V, nitrofurantoin, sulfonamides, tetracycline & INH) & pain (analgesic, anti-migraine & tranquilizer) & hepatic enzyme inducers eg, antiepileptics (carbamazepine, oxcarbazepine, felbamate, topiramate, phenytoin), antifungal (griseofulvin), antidiabetic (troglitazone), musculoskeletal (phenylbutazone) & anti-TB drugs (rifampicin). May inhibit cytochrome P450 isoenzyme 3A4 w/ anti-infectives (eg, clarithromycin, erythromycin, itraconazole, ketoconazole, ritonavir) or grapefruit juice. Increased risk of cholestatic jaundice w/ troleandomycin.