Not to be administered w/ other long-acting β-agonists or long-acting muscarinic-antagonists. Not to be used in asthma. Not for acute use; do not use as rescue therapy. Discontinue immediately & institute alternative therapy if hypersensitivity & paradoxical bronchospasm occurs. Narrow-angle glaucoma & urinary retention. CV disorders (CAD, acute MI, cardiac arrhythmias, HTN); convulsive disorders or thyrotoxicosis; in patients who are unusually responsive to β2
-adrenergic agonists. Clinically significant CV effect as measured by increases in pulse rate, BP, &/or symptoms, ECG changes. Significant hypokalemia in some patients, which has the potential to produce adverse CV effects. Hypokalemia may be potentiated by hypoxia & concomitant treatment which may increase susceptibility to cardiac arrhythmias in patients w/ severe COPD. Hyperglycemia. Closely monitor plasma glucose in diabetic patients. Severe hepatic & renal impairment or end-stage renal disease requiring dialysis. May inhibit labor due to relaxant effect on uterine smooth muscle. Pregnancy & lactation. Childn <18 yr.