Unasyn Oral

Unasyn Oral





Concise Prescribing Info
Sultamicillin tosylate
Upper resp tract infections including sinusitis, otitis media & tonsillitis; lower resp tract infections including bacterial pneumonia & bronchitis; UTI & pyelonephritis; skin & soft tissue, intra-abdominal & gonococcal infections. Patients requiring sulbactam/ampicillin therapy following initial treatment w/ sulbactam/ampicillin IM/IV.
Dosage/Direction for Use
Adult (including elderly) 375-750 mg bid. Treatment is continued until 48 hr after pyrexia & other abnormal signs have resolved. Duration of treatment: 5-14 days. Uncomplicated gonorrhea 2.25 g as single dose + 1 g probenecid. Infections caused by hemolytic strep Administer for at least 10 days to prevent occurrence of acute rheumatic fever or glomerulonephritis. Childn ≥30 kg Give usual adult dose; <30 kg 25-50 mg/kg/day in 2 divided doses.
May be taken with or without food.
History of allergic reaction to any of the penicillins.
Special Precautions
Serious & occasionally fatal hypersensitivity (anaphylactic) reactions. Toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis & erythema multiforme. Consider diagnosis of Clostridium difficile-associated diarrhea in patients who present diarrhea following antibiotic use. Drug induced liver injury eg, cholestatic hepatitis & jaundice. Increased risk of skin rash in patients w/ mononucleosis. Periodically check for organ system dysfunction during prolonged therapy. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Pregnancy. Not recommended during lactation. Neonates.
Adverse Reactions
Pseudomembranous colitis, candida infection; thrombocytopenia; anaphylactic shock/reaction, hypersensitivity, Kounis syndrome; dizziness, somnolence, sedation, headache; dyspnea; GI disorders; jaundice, abnormal hepatic function; toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, angioedema, urticaria, dermatitis, rash, pruritus; arthralgia; fatigue, malaise; increased AST/ALT.
Drug Interactions
Increased incidence of rashes w/ allopurinol. Additive effect w/ anticoagulants. May interfere bactericidal effect w/ bacteriostatic drugs (chloramphenicol, erythromycin, sulfonamides & tetracyclines). Reduced OC effectiveness. Decreased clearance of methotrexate. Decreased renal tubular secretion w/ probenecid. False +ve glycosuria using Benedict's/Fehling's reagent & Clinitest.
MIMS Class
ATC Classification
J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Unasyn Oral FC tab 750 mg
8's (P930.74/pack)
Unasyn Oral FC tab 375 mg
100's (P9,368.31/pack)
Unasyn Oral oral susp 250 mg/5 mL
60 mL x 1's (P620.39/bottle)
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