Valvex A (80/5)/Valvex A (160/5)/Valvex A (160/10)

Valvex A (80/5)/Valvex A (160/5)/Valvex A (160/10)

amlodipine + valsartan

Manufacturer:

Vexxa Lifesciences

Distributor:

VE Pharma
Concise Prescribing Info
Contents
Per 80 mg/5 mg tab Valsartan 80 mg, amlodipine besilate 5 mg. Per 160 mg/5 mg tab Valsartan 160 mg, amlodipine besilate 5 mg. Per 160 mg/10 mg tab Valsartan 160 mg, amlodipine besilate 10 mg
Indications/Uses
Treatment of essential HTN in adults whose BP is not adequately controlled on amlodipine or valsartan monotherapy.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to valsartan, amlodipine besilate & dihydropyridine derivatives. Severe hepatic impairment, biliary cirrhosis or cholestasis; renal impairment; hypotension; cardiogenic shock; obstruction of the outflow tract of the left ventricle (eg, hypertrophic obstructive cadiomyopathy & high grade aortic stenosis); hemodynamically unstable heart failure after acute MI.
Special Precautions
Hypertensive crisis. Na &/or vol-depleted patients; hyperkalemia; renal artery stenosis; kidney transplantation; primary aldosteronism; angioedema; heart failure/post MI; aortic & mitral valve stenosis. Pregnancy. Childn <18 yr. Elderly ≥65 yr.
Drug Interactions
Increased antihypertensive effects w/ α-blockers, diuretics; TCAs. Amlodipine: Increased BP-lowering effects w/ grapefruit or grapefruit juice. Increased exposure w/ CYP3A4 inhibitors (PIs, azole antifungals, macrolides eg, erythromycin or clarithromycin, verapamil or diltiazem). Potential lowering of plasma conc w/ CYP3A4 inducers (eg, rifampicin, Hypericum perforatum). Simvastatin; dantrolene. Valsartan: Lithium; NSAIDs including selective COX-2 inhibitors, acetylsalicylic acid (>3 g/day) & nonselective NSAIDs. Increased systemic exposure w/ uptake transporter (rifampicin, ciclosporin) or efflux transporter (ritonavir).
ATC Classification
C09DB01 - valsartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Valvex A 160 mg/5 mg FC tab
Packing/Price
30's
Form
Valvex A 160 mg/10 mg FC tab
Packing/Price
30's
Form
Valvex 80 mg/5 mg FC tab
Packing/Price
30's
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