Van-CP 500/Van-CP 1G

Van-CP 500/Van-CP 1G

vancomycin

Manufacturer:

BioRx Pharma Labs

Distributor:

Ambica
Concise Prescribing Info
Contents
Vancomycin HCl
Indications/Uses
Concomitant w/ oral use: Potentially life-threatening infections due to susceptible gm +ve organisms which cannot be treated by other effective, less toxic antimicrobials; agent of choice in methicillin-resistant staphylococcal infection. Severe staphylococcal infections in patients who cannot receive or failed to respond to penicillins & cephalosporins or have infection w/ staphylococci resistant to other antibiotics including methicillin. Prophylaxis against endocarditis in patients at risk from dental or surgical procedures.
Dosage/Direction for Use
IV Adult 500 mg every 6 hr or 1 g every 12 hr administered at ≤10 mg/min. Bacterial endocarditis 500 mg every 6 hr for a min of 3 wk alone or in combination w/ other antibiotics. Childn 10 mg/kg very 6 hr over a period of at least 60 min. Neonate & young infant Initially 15 mg/kg followed by 10 mg/kg every 12 hr in 1st wk of life & every 8 hr thereafter until 1 mth of age. Impaired renal function Start at 15 mg/kg. CrCl 2 mL/min/kg 30.9 mg/kg/24 hr; 1.5 mL/min/kg 23.2 mg/kg/24 hr; 1 mL/min/kg 15.4 mg/kg/24 hr; 0.5 mL/min/kg 7.7 mg/kg/ 24 hr; 0.2 mL/min/kg 3.1 mg/kg/24 hr.
Special Precautions
Not for IM use. Occasional severe hypotension (including shock & rare cardiac arrest), histamine-like responses & maculopapular or erythematous rash. Patients w/ previous hearing loss. Pain & thrombophlebitis may occur. May enhance anaesth induced myocardial depression. Conduct periodic haematological studies, urine analysis, liver & renal function tests. Avoid use w/ nephrotoxic drugs. Renal impairment. Pregnancy. Not recommended during lactation.
Adverse Reactions
Permanent or reversible deafness; hypotension, palpitations, substernal pressure, phlebitis; pruritus at inj site, generalized flushing, erythematous macular rash w/ intense pruritus over face, neck & upper body (too rapid inj); extravasation (IV site); bullous eruption disorders, rashes including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis & linear IgA bullous dermatosis; overgrowth of nonsusceptible organisms; transient elevations of urea & granular cast in urine; reversible neutropenia, eosinophilia; chills, nausea, urticaria, macular rash, fever, rigors; anaphylactoid & hypersensitivity reactions, & anaphylaxis; pain & muscle spasm of chest & back.
Drug Interactions
Associated w/ erythema, histamine-like flushing & anaphylactoid reactions w/ anesth. Concurrent administration w/ other neurotoxic or nephrotoxic drugs eg, amphotericin B, streptomycin, neomycin, gentamicin, kanamycin, amikacin, tobramycin, bacitracin, polymyxin B, colistin & cisplatin. May aggravate ototoxicity w/ diuretics eg, ethacrynic acid & furosemide. May bind w/ cholestyramine in vitro.
MIMS Class
Other Antibiotics
ATC Classification
J01XA01 - vancomycin ; Belongs to the class of glycopeptide antibacterials. Used in the systemic treatment of infections.
Presentation/Packing
Form
Van-CP 1G powd for inj 1 g
Packing/Price
20 mL x 1's
Form
Van-CP 500 powd for inj 500 mg
Packing/Price
10 mL x 1's
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