Vasolexin

Vasolexin

carvedilol

Manufacturer:

Korea United Pharma

Distributor:

Pharma 3
Concise Prescribing Info
Contents
Carvedilol
Indications/Uses
Treatment of HTN & angina pectoris. Adjunct to diuretics, digoxin or ACE inhibitors in symptomatic chronic heart failure.
Dosage/Direction for Use
HTN Adult Initially 12.5 mg once daily, increased to 25 mg once daily after 2 days. Alternative: Initially 6.25 mg bid, increased to 12.5 mg bid after 1-2 wk. Dose may be increased to 50 mg once daily or in divided doses at intervals of at least 2 wk. Elderly 12.5 mg once daily. Angina pectoris Initially 12.5 mg bid, increased to 25 mg bid after 2 days. Heart failure Initially 3.125 mg bid. Dose may be doubled to 6.25 mg bid after 2 wk, then gradually increased at intervals of not <2 wk. Patient weighing >85 kg Max: 50 mg bid, <85 kg Max: 25 mg bid.
Administration
Should be taken with food.
Contraindications
Cardiogenic shock or NYHA class IV decompensated heart failure requiring IV inotropic support, resp disease eg, asthma & COPD w/ a bronchospastic component, secondary HTN, acute pulmonary arterial embolism, 2nd- & 3rd-degree AV block, sick-sinus syndrome, SA block, severe bradycardia, metabolic acidosis, concomitant MAOI therapy (except MAO-B inhibitor), severe hypotension, hepatic impairment, acute MI w/in 4 wk after onset of disease.
Special Precautions
Patients w/ peripheral vascular disease especially in Raynaud's disease; cardiac failure over NYHA class II. Pheochromocytoma; diabetes; CHF patients w/ diabetes; history of serious hypersensitivity reactions & those undergoing desensitization therapy; history of psoriasis associated w/ β-blocker therapy; ischemic heart disease, diffuse angiosis or renal adequacy w/ hypotension; unstable angina, Prinzmetal's variant angina; 1st-degree AV block. Monitor cardiac function regularly. May obscure symptoms of cardiothyrotoxicosis. Abrupt w/drawal. Possibility of reduced lacrimation in wearing contact lenses. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn & patients <18 yr. Elderly >70 yr.
Adverse Reactions
Dizziness, headache, fatigue; edema, high-degree bradycardia & cardiac failure & complete AV block, reduced pulse frequency, systemic vascular disorder, increased resp tract resistance, urticaria, pruritus & lichen planus-like reaction, pain in the extremities.
Drug Interactions
Increased conc of digoxin. Sedatives eg, barbiturate & phenothiazine, antidepressant, vasodilator, alcohol. Reduced cardiac rate w/ reserpine, guanethidine, methyldopa, clonidine, guanfacine. Avoid IV use w/ Ca channel blockers eg verapamil/diltiazem type or type 1 antiarrhythmics. May reduce effect of descending BP w/ COX inhibitor eg, aspirin & corticosteroid. May enhance insulin or hypoglycemic effect. Increased serum levels w/ inducers/inhibitors of mixed function oxidases eg rifampicin & cimetidine. Synergistic -ve inotropic & hypotensive effects w/ anesth. Monitor cyclosporine conc.
MIMS Class
ATC Classification
C07AG02 - carvedilol ; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Vasolexin tab 6.25 mg
Packing/Price
100's (P840.72/box)
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