Pharmacology: Pharmacodynamics: Mechanism of Action: Diosmin + Hesperidin is a phlebotonic drug and a vascular-protecting agent.
The efficacy of Diosmin + Hesperidin is accounted for by its specific action on the principal elements of venous disease.
Diosmin + Hesperidin is phlebotonic: It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus, Diosmin + Hesperidin decreases venous capacitance, venous distensibility and venous emptying time.
Diosmin + Hesperidin protects the microcirculation by fighting the microcirculation-damaging process; it combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, Diosmin + Hesperidin normalizes capillary permeability and strengthens capillary resistance.
Diosmin + Hesperidin acts on the lymphatic system: It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure. This action on the lymphatic system associated with a phlebotonic and vasculoprotective effect, explains the activity of Diosmin + Hesperidin on CVD-associated edema.
Double-blind, placebo-controlled studies have demonstrated Diosmin + Hesperidin's efficacy on chronic venous disease. Diosmin + Hesperidin significantly improves disabling symptoms of venous insufficiency which affect everyday active life: Heavy legs, pain, heat sensation, edema, functional impairment and nocturnal cramps.
In addition to conventional compression therapy, Diosmin + Hesperidin has been shown to accelerate complete healing of venous leg ulcers.
Diosmin + Hesperidin is highly effective in the treatment of chronic hemorrhoidal disease. It significantly improves subjective symptoms and objective signs eg, anal discomfort, pain, redness, anal discharge, proctitis, tenesmus, pruritus, erythema and bleeding. Diosmin + Hesperidin also significantly reduces the frequency, severity and duration of acute hemorrhoidal attacks and bleeding by chronic treatment.